![]() Emerging role of human basophil biology in health and disease. ![]() The biology of eosinophils and their role in asthma. The multifaceted functions of neutrophils. It can be treated with certain cancer drugs called JAK inhibitors and, in some cases, stem cell transplants. Symptoms of primary myelofibrosis include fatigue, itching, night sweats, and weight loss. It can cause higher than normal WBCs, but over time, the cells made by the bone marrow usually decrease because the tissue can no longer work as it should. Primary myelofibrosisis a rare disease that causes bone marrow to be replaced with scar-like tissue that eventually leads the tissue to fail.It can be treated with drugs to help prevent blood clots (like aspirin and warfarin) and medications that reduce the number of cells in the bone marrow). Symptoms include fatigue, headaches, and visual changes. It can result in blood clots and complications like heart attacks and strokes and may turn into other blood cancers. Essential thrombocythemia is a rare blood disorder that causes too many platelets but it can also lead to slightly higher than normal WBCs.Treatment for CML includes medications and in some cases, a bone marrow transplant. This type of cancer is slow and takes years to develop, so the symptoms can be general like fatigue, or an enlarged spleen. Chronic myelogenous leukemia (CML) is a blood cancer where the bone marrow makes too many WBCs.Polycythemia vera can be treated with medications that suppress the bone marrow and prevent blood clots, as well as having blood taken often to lower the volume of cells (therapeutic phlebotomy). It can also cause itchy skin after a hot shower or bath. It can cause general symptoms like fatigue and shortness of breath, as well as bleeding problems like heavy menstrual periods and nose bleeds. Polycythemia vera is a rare type of blood cancer that usually affects red blood cells and platelets but may also lead to high WBCs.
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